William Tam

Publications

2021

151. Austin Pounder, Angel Ho, Matthew Macleod and William Tam*
"Chemistry of Unsymmetrical C1-Substituted Oxabenzonorbornadienes"
Curr. Org. Syn. 2021, 18, 446–474.

150. Austin Pounder, Leanne D. Chen*, and William Tam
"The Mechanism and Origin of Enantioselectivity in the Rhodium-Catalyzed Asymmetric Ring-Opening Reactions of Oxabicyclic Alkenes with Organoboronic Acids: A DFT Investigation"
Organometallics 2021, 40, 1588–1597.

149. Austin Pounder, Fiona Bishop, Leanne D. Chen*, and William Tam*
"A DFT Study on the Mechanism and Origin of Regioselectivity in the Rhodium/Diene-Catalyzed Ring-Opening Reactions of C1-Substituted Oxabenzonorbornadienes with Arylboronic Acids"
Eur. J. Org. Chem. 2021, 1901–1908.

148. Austin Pounder, Leanne D. Chen,* and William Tam*
"Ruthenium-Catalyzed [2 + 2] versus Homo Diels−Alder [2 + 2 + 2] Cycloadditions of Norbornadiene and Disubstituted Alkynes: A DFT Study"
ACS Omega 2021, 6, 900-911.

2020

147. Samuel Koh, Austin Pounder, Elizabeth Brown and William Tam*
"Intramolecular Nickel-Catalyzed Ring-Opening Reactions of Oxabenzonorbornadienes with C1-Tethered Aryl Halides: An Improvement of Method"
Eur. J. Org. Chem. 2020, 4558-4562.

146. Samuel Koh, Austin Pounder, Elizabeth Brown and William Tam*
"Intramolecular Palladium-Catalyzed Ring Opening of Oxabenzonorbornadienes with C1-Tethered Aryl Halides"
Org. Lett. 2020, 22, 3433–3437.

145. Nawaz Ahmed, Behnoush Kermanshahi, Saeed M. Ghazani, Katrina Tait, Matthew Tcheng, Alessia Roma, Shannon P. Callender, Richard W. Smith, William Tam,, Shawn D. Wettig, Michael A. Rogers , Alejandro G. Marangoni & Paul A. Spagnuolo*
"Avocado-derived polyols for use as novel co-surfactants in low energy self-emulsifying microemulsions"
Scientific Reports - Nature 2020, 10, 5566.

144. Alan J. Lough, Samuel Koh and William Tam*
"12,15-Dimethyl-8-oxatetracyclo[8.8.0.02,7.011,16]-octadeca-1(18),2,4,6,11(16),12,14-heptaen-10-ol"
IUCrData 2020, 5, x200315.

143. Alan J. Lough, Austin Pounder, Christopher Wicks and William Tam*
"1,2,3,5-Tetrahydronaphtho[2,1-c]oxepine"
IUCrData 2020, 5, x200288.

142. Alan J. Lough, Austin Pounder and William Tam*
"12-Ethyl-6a,10a-dihydro-5H-6-oxachrysene"
IUCrData 2020, 5, x200286.
 

141. Alan J. Lough, Angel Ho and William Tam*
"[(1R*,3S*,4S*)-3-(2-Hydroxybenzoyl)-1,2,3,4-tetrahydro-1,4-epoxynaphthalen-1-yl]methyl 4-nitrobenzoate"
IUCrData 2020, 5, x200265.

2019

140. Christopher Wicks, Samuel Koh, Austin Pounder, Emily Carlson, and William Tam*
"Acid-Catalyzed Intramolecular Ring-Opening Reactions of Cyclopropanated Oxabenzonorbornadienes with Alcohol Nucleophiles"
Tetrahedron Lett. 2019, 60, article 151228.

139. Dina Petko, Austin Pounder and William Tam*
"Ruthenium-Catalyzed [2+2+2] Bis-Homo-Diels Alder Cycloadditions of 1,5-Cycloocatadiene with Alkynyl Phosphonates"
Synthesis 2019, 51, 4271–4278.

138. Dina Petko, Matthew Stratton, Samuel Koh and William Tam*
"Cationic Ruthenium-Catalyzed Bis-Homo-Diels-Alder Cycloaddition"
Curr. Org. Syn. 2019, 16, 787–792.

137. Jarvis Hill, Christopher Wicks, Austin Pounder and William Tam*
"Iridium Catalyzed Ring-Opening Reactions of Unsymmetrical Oxabenzonorbornadienes with Water and Alcohol Nucleophiles"
Tetrahedron Lett. 2019 60, article 150990.

136. Dina Petko, Samuel Koh and William Tam*
"Transition Metal-Catalyzed Reactions of Alkynyl Halides"
Curr. Org. Syn. 2019, 16, 546–582.

135. Rebecca Boutin, Samuel Koh and William Tam* (Invited Review)
"Recent Advances in Transition Metal-Catalyzed Reactions of Oxabenzonorbornadiene"
Curr. Org. Syn. 2019, 16, 460–484.

134. Jarvis Hill and William Tam*
"Palladium/Lewis Acid Co-Catalyzed Ring-Opening Reactions of Unsymmetrical Oxabenzonobornadienes with Oximes"
J. Org. Chem. 2019 84, 8309–8314.

133. Alan J. Lough, Jarvis Hill and William Tam*
"1-[(1R*,2R*)-1,2-Dihydroxy-1,2-dihydronaphthalen-1-yl]ethan-1-one"
IUCrData 2019, 4, x190609.

132. Katrina Tait, Samuel Koh, Nicolas Blanchard and William Tam*
"Ruthenium-Catalyzed Ring-Opening Reaction of a 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene with Amines – An Unexpected Mode of Ring-Opening"
Can. J. Chem. 2019, 97, 310–316.

2018

131. Dina Petko, Matthew Stratton and William Tam*
"Ruthenium-catalyzed Bis-Homo-Diels-Alder Reaction: Searching for Commercially Available Catalysts and Expanding the Scope of Reaction"
Can. J. Chem. 2018, 96, 1115–1121.

130. Emily Carlson, Rebecca Boutin and William Tam*
"Type 3 ring opening reaction of cyclopropanated oxabenzonorbornadienes with alcohol nucleophiles"
Tetrahedron 2018, 74, 5510–5518.

129. Katrina Tait and William Tam*
"Transition Metal-Catalyzed Reactions of 3-Aza-2-oxabicyclo[2.2.1]hept-5-enes"
Curr. Org. Syn. 2018, 15, 762–780.

2017

128. Katrina Tait, Alysia Horvath, Nicolas Blanchard and William Tam* "Acid-catalyzed ring-opening reactions of a cyclopropanated 3-aza-2-oxabicyclo[2.2.1]hept-5-ene with alcohols" Beilstein J. Org. Chem. 2017, 13, 2888–2894.

127. Alan J. Lough, Katrina Tait, Alysia Horvath and William Tam* "N-(1R,2R,4R,5S)-rel-4-tert-Butoxybicyclo[3.1.0]hex-2-yl(hydroxyamino) 2,2-dimethylpropionate" IUCrData 2017, 2, x171419.

126. Alan J. Lough, Katrina Tait and William Tam* "tert-Butyl (3-oxocyclopentyl)carbamate" IUCrData 2017, 2, x171418.

125. Alan J. Lough, Emily Carlson and William Tam* “(5R, 6R)-rel-9-tert-butyl-trans-5,6-dimethoxy-6,7-dihydro-5H-benzocycloheptene” IUCrData 2017, 2, x171417.

2016

124. Katrina Tait, Oday Alrifai, Rebecca Boutin, Jamie Haner and William Tam*.
“Palladium-catalyzed Ring-Opening Reactions of Cyclopropanated 7-Oxabenzonorbornadiene with Alcohols”
Beil. J. Org. Chem. 2016, 12, 2189–2196.

123. Emily Carlson, Daniel Hong and William Tam*.
“Type 2 Ring-Opening Reactions of Cyclopropanated 7-Oxabenzonorbornadienes with Carboxylic Acid Nucleophiles”
Synthesis 2016, 48, 4253–4259.

122. Emily Carlson and William Tam*
“Synthesis of Cyclopropanated 7-Azabenzonorbornadienes”
Synthesis 2016, 48, 2449–2454.

121. Emily Carlson and William Tam*
“Type 1 Ring-Opening Reactions of Cyclopropanated 7-Azabenzonorbornadienes with Organocuprates”
Org. Lett. 2016, 18, 2134–2137.

120. Alan J. Lough, Emily Carlson and William Tam*
“(1aR, 2R, 7S, 7aS)-rel-1a,2,7,7a-Tetrahydro-3,6-dimethoxy-2-methyl-2,7-epoxy-1H-cyclopropa[b]naphthalene”
IUCrData 2016, x160341.
 
119. Michael Edmunds, Mohammed Abdul Raheem, Rebecca Boutin, Katrina Tait and William Tam*. 2016.
“Regioselective palladium catalyzed ring-opening reactions of C1 substituted oxabicyclo[2,2,1]hepta-2,5-diene-2,3-dicarboxylates”
Beil. J. Org. Chem. 2016, 12, 239–244.

118. Emily Carlson, Guillaume Duret, Nicolas Blanchard, and William Tam*
“Synthesis of Cyclopropanated [2.2.1] Heterobicycloalkenes: An Improved Procedure”
Synth. Commun. 2016, 46, 55–62.
 
2015

117. Michael Edmunds, Michelle L. Menard and William Tam*
“Study on the Regioselectivity of Rhodium-Catalyzed Ring Opening Reactions of C1 Substituted 7-Oxabenzonorbornadienes with Boronic Acids”
Synth. Commun. 2015, 45, 468–476.

2014

116. Jordan Goodreid, Karine Villeneuve, Emily Carlson and William Tam*.
“Ruthenium-Catalyzed Asymmetric [2+2] Cycloadditions between Chiral Acetylenic Acyl Camphorsultam-Substituted Alkynes and Bicyclic Alkenes”
J. Org. Chem. 2014, 79, 10002–10012.

115. Jaipal R. Nagireddy, Geoffrey K. Tranmer, Emily Carlson and William Tam*.
“N-O Cleavage reactions of bicycloalkene-fused 2-isoxazolines”
Beil. J. Org. Chem. 2014, 10, 2200–2205.

114. Andrew Tigchelaar, Jamie Haner, Emily Carlson, and William Tam*.
“Type 2 Ring-Opening Reactions of Cyclopropanated 7-Oxabenzonorbornadienes under Acid Catalysis”
Synlett 2014, 25, 2355–2359.

113. Gavin C. Tsui, Karine Villeneuve, Emily Carlson and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions between Norbornene and Propargylic Alcohols or their Derivatives”
Organometallics 2014, 33, 3847–3856.

112. Jaipal R. Nagireddy, Emily Carlson and William Tam*.
“1,3-Dipolar cycloaddition of C1-substituted 7-oxabenzonorbornadienes”
Can. J. Chem. 2014, 92, 1053–1058.

111. Mohammed Abdul Raheem, Michael Edmunds, William Tam*.
“Regioselective Palladium Catalyzed Ring-opening Reactions of C1 substituted Oxabenzonorbornadienes”
Can. J. Chem. 2014, 92, 888–895.

110. Jaipal R. Nagireddy, Emily Carlson, William Tam*.
“1,3-Dipolar Cycloadditions of Nitrile Oxides with 7-Oxa- and 7-Azabenzonorbornadienes”
Can. J. Chem. 2014, 92, 635–639.

109. Alan J. Lough, Mohammed-Abdul Raheem and William Tam.
“cis-2-(4-Methoxyphenyl)-4-methyl-1,2-dihydronaphthalen-1-ol”
Acta Cryst. 2014, E70, o546.

108. Alan J. Lough, Jaipal Nagireddy and William Tam.
“1-(3-Hydroxy-5,8-dimethoxy-4-methyl-1,2,3,4-tetrahydro-1,4-epoxynaphthalen-2-yl)ethan-1-one”
Acta Cryst. 2014, E70, o545.

107. Alan J. Lough, Jaipal Nagireddy and William Tam.
“5,8-Dimethoxy-3,9-dimethyl-3a,4,9,9a-tetrahydro-4,9-epoxynaphtho[2,3-d ]isoxazole”
Acta Cryst. 2014, E70, o544.

106. Alan J. Lough, Jaipal Nagireddy and William Tam.
“(3-Methyl-3a,4,7,7a-tetrahydro-5H-4,7-methanoisoxazolo[4,5-d ][1,2]oxazin-5-yl)(phenyl)methanone”
Acta Cryst. 2014, E70, o543.

105. Emily Carlson, Jamie Haner, Mary McKee and William Tam*
“Type 1 Ring-Opening Reactions of Cyclopropanated 7-Oxabenzonorbornadienes with Organocuprates”
Org. Lett. 2014, 16, 1776–1779.

104. Mary McKee, Jamie Haner, Emily Carlson and William Tam*.
“Synthesis of Cyclopropanated 7-Oxabenzonorbornadienes”
Synthesis 2014, 46, 1518–1524.

2013

103. Kelsey Jack, Ben Machin, Andrew Tigchelaar and William Tam*.
“Synthesis of Substituted Norbornadienes.”
Curr. Org. Syn. 2013, 10, 584–630.

102. Kelsey Jack and William Tam*.
“Ruthenium-Catalyzed Dimerization of 7-Oxabicyclo[2,2,1]hepta-2,5-diene-2,3-dicarboxylates.”
J. Org. Chem. 2013, 78, 3416–3420.

101. Kelsey Jack, Elisabeth Fatila, Colleen Hillis and William Tam*.
“Ruthenium-Catalyzed Nucelophilc Ring-Opening Reactions of 7-Oxabenzonorbornadienes with Methanol.”
Synth. Commun. 2013, 43, 1181–1187.

100. Kelsey Jack, Jordan Goodreid, Neil Cockburn and William Tam*. (invited Book Chapter)
“Transition Metal-Catalyzed [2+2] Cycloaddition Reactions Between Bicyclic Alkenes and Alkynes.” in “Advances in Organic Synthesis”, Editor: Atta-ur-Rahman, Bentham Science Publishers. 2013, Vol. 6, Chapter 2, pp. 59–114.

99. Mohammed-Abdul Raheem and William Tam*.
“Synthesis of C1-Substituted 7-Oxanorbornadienes.”
Synth. Commun. 2013, 43, 260–267.

2012

98. Andrew Tigchelaar and William Tam*.
“Iridium-Catalyzed Intramolecular [4+2] Cycloadditions of Alkynyl Halides”
Beil. J. Org. Chem. 2012, 8, 1765–1770.

97. Alan J. Lough, Kelsey Jack and William Tam.
“Hexamethyl 13,14-dioxapentacyclo[8.2.1.14,7.02,9.03,8]tetradeca-5,11-diene-1,4,5,6,11,12-hexacarboxylate”
Acta Cryst. 2012, E68, o2963.

96. Alan J. Lough, Kelsey Jack and William Tam.
“Tetra-tert-butyl 13,14-dioxapentacyclo[8.2.1.14,7.02,9.03,8]tetradeca-5,11-diene-5,6,11,12-tetracarboxylate”
Acta Cryst. 2012, E68, o2962.

95. Alan J. Lough, Kelsey Jack and William Tam.
“Tetramethyl 1,4-dimethyl-13,14-dioxapentacyclo[8.2.1.14,7.02,9.03,8]tetradeca-5,11-diene-5,6,11,12-tetracarboxylate”
Acta Cryst. 2012, E68, o2961.

94.  Jamie Haner, Kelsey Jack, Michelle L. Menard, Jennifer Howell, Jaipal Nagireddy, Mohammed Abdul Raheem and William Tam*.
“Synthesis of C1-Substituted Oxabenzonorbornadienes”
Synthesis 2012, 44, 2713–2722.

2011

93. Robin Durham, Jérémie Mandel, Nicolas Blanchard, and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloaddition Reactions of a 2-Oxa-3-azabicyclo[2.2.1]hept-5-ene with Unsymmetrical Alkynes.”
Can. J. Chem. 2011, 89, 1494–1505.

92. Tanner K. Kettles and William Tam*. (Invited Review)
“7-tert-Butoxy-Bicyclo[2.2.1]hepta-2,5-diene.”
In “Encyclopedia of Reagents for Organic Synthesis”, Editors: Crich, D.; Fuchs, P. L.; Charette, A. B.; Rovis, T., John Wiley & Sons Ltd., 2011, article number RN01412.

91. Tanner K. Kettles and William Tam*. (Invited Review)
“Bicyclo[2.2.1]hepta-2,5-diene (Norbornadiene) (Unique ID RN01411).”
In “Encyclopedia of Reagents for Organic Synthesis”, Editors: Crich, D.; Fuchs, P. L.; Charette, A. B.; Rovis, T., John Wiley & Sons Ltd., 2011, article number RN01411.

90. Jaipal R. Nagireddy, Mohammed-Abdul Raheem, Jamie Haner and William Tam*.
“Methods of Cleavage of 2-Isoxazolines.”
Curr. Org. Syn. 2011, 8, 659–700.

89. Tanner J. Kettles, Neil Cockburn and William Tam*.
“Ruthenium-Catalyzed Homo Diels-Alder [2+2+2] Cycloadditions of Alkynyl Phosphonates with
Bicyclo[2.2.1]hepta-2,5-diene.”
J. Org. Chem. 2011, 76, 6951–6957.

88. Alan J. Lough, David A. Petrone and William Tam.
“(1S,2S,4R)-7-tert-Butoxybicyclo[2.2.1]hept-5-en-2-yl (2S)-2-(6-methoxynapthalen-2-yl)propanoate.”
Acta Cryst. 2011, E67, o1848.

87. Jamie Haner, Kelsey Jack, Jaipal R. Nagireddy, Mohammed-Abdul Raheem, Robin Durham and William Tam*.
“Synthesis of 2-Substituted Furans by Iron- and Palladium-Catalyzed Coupling Reactions”
Synthesis 2011, 731–738.

2010

86. Neil Cockburn and William Tam*.
“Bicyclic Alkenes: From Cycloadditions to the Discovery of New Reactions.”
Synlett. 2010, 1170–1189.

85. Mohammed-Abdul Raheem, Jaipal R. Nagireddy, Robin Durham and William Tam*.
“Efficient Procedure for the Preparation of 2-Bromofuran and its Application in the Synthesis of 2-Arylfurans.”
Synth. Commun. 2010, 40, 2138–2146.

2009

84. Jordan D. Goodreid, Michael C. Jennings* and William Tam.
“Asymmetric ruthenium-catalysed [2+2] cycloadditions between bicyclic alkenes and chiral aryl-
substituted acetylenic acyl camphorsultam alkynes”
Acta Cryst. 2009, C65, o649–o652.

83. Melissa Ballantine, Michelle L. Menard and William Tam*.
“Isomerization of 7-Oxabenzonorbornadienes into Naphthols Catalyzed by [RuCl2(CO)3]2.”
J. Org. Chem. 2009, 74, 7570–7573.

82. Ben P. Machin, Melissa Ballantine, Jérémie Mandel, Nicolas Blanchard and William Tam*
“Rhodium-Catalyzed Ring Opening Reactions of a 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene with Arylboronic Acids.”
J. Org. Chem. 2009, 74, 7261–7266.

81. Neil Cockburn, Elham Karimi and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions of Bicyclic Alkenes with Alkynyl Phosphonates”
J. Org. Chem. 2009, 74, 5762–5765.

80. Jordan Goodreid, Neil Cockburn and William Tam*.
“Transition Metal-Catalyzed [2+2] Cycloaddition Reactions Between Bicyclic Alkenes and Alkynes”
Curr. Org. Syn. 2009, 6, 219–238.

79. Alan J. Lough, Ben P. Machin and William Tam.
“tert-Butyl N-hydroxy-N-[(1S*,2R*)-2-(1-naphthyl)cyclopent-3-en-1-yl]carbamate.”
Acta Cryst. 2009, E65, o1481.

78. Ben P. Machin, Jennifer Howell, Jérémie Mandel, Nicolas Blanchard and William Tam*
“Ruthenium-Catalyzed Nucleophilic Ring-Opening Reactions of a 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene with Alcohols”
Org. Lett. 2009, 11, 2077–2080.

77. Jennifer Howell, John D. Goddard* and William Tam.
“A relative approach for determining ring strain energies of heterobicyclic alkenes”
Tetrahedron 2009, 65, 4562–4568.

76. Gavin C. Tsui, Paul Le Marquand, Anna Allen and William Tam*.
“Synthesis of anti-2,7-Disubstituted Norbornadienes”
Synthesis 2009, 609–619.

2008

75. Paul Le Marquand, Gavin C. Tsui, John C. C. Whitney and William Tam*.
“Iron-Catalyzed Cross-coupling Reactions Between a Bicyclic Alkenyl Triflate and Grignard Reagents”.  
J. Org. Chem. 2008, 73, 7829–7832.

74. Anna Allen, Karine Villeneuve, Neil Cockburn, Elisabeth Fatila, Nicole Riddell and William Tam*.
“Alkynyl Halides in Ruthenium(II)-Catalyzed [2+2] Cycloadditions of Bicyclic Alkenes”
Eur. J. Org. Chem. 2008, 4178–4192.

73. Paul Le Marquand and William Tam*.
“Enantioselective Palladium-Catalyzed [3+2] Trimethylenemethane Cycloadditions”
Angew. Chem. Int. Ed. 2008, 47, 2926–2928.

72. Robert W. Jordan, Paul Le Marquand and William Tam*.
“Ruthenium(II)-Catalyzed [2+2] Cycloadditions of anti 7-Substituted Norbornenes”
Eur. J. Org. Chem. 2008, 80–86.

2007

71. Karine Villeneuve and William Tam*.
“Construction of Isochromenes via Ruthenium-Catalyzed Reaction of Oxabenzonorbornenes with Propargylic Alcohols”
Organometallics 2007, 26, 6082–6090.

70. Anna Allen, Paul Le Marquand, Ryan Burton, Karine Villeneuve and William Tam*.
“Rhodium-Catalyzed Asymmetric Cyclodimerization of Oxabenzonorbornadienes and Azabenzonorbornadienes: Scope and Limitations”
J. Org. Chem. 2007, 72, 7849–7857.

69. Ryan R. Burton and William Tam*.
“Study on the Reactivity of Oxabicyclic Alkenes in Ruthenium-Catalyzed [2+2] Cycloadditions”
J. Org. Chem. 2007, 72, 7333–7336.

68. Ryan R. Burton, William Tam*.
“Ruthenium(II)-Catalyzed Cyclization of Azabenzonorbornadienes with Alkynes”
Org. Lett. 2007, 9, 3287–3290.

67. Alan J. Lough*, Anna Allen and William Tam.
“Cyclodimerization product of benzooxanorbornadiene.”
Acta Cryst. 2007, E63, o1462–o1463.

66. Peng Liu, William Tam and John D. Goddard*.
“Ruthenium Catalyzed [2+2] Cyloadditions between Substituted Alkynes and Norbornadiene:
A Theoretical Study.”
Tetrahedron, 2007, 63, 7659–7666.

2006

65. Karine Villeneuve and William Tam*.
“Ruthenium(II)-Catalyzed Cyclization of Oxabenzonorbornenes with Propargylic Alcohols: Formation of Isochromenes.”
Eur. J. Org. Chem. 2006, 5449–5453.

64. Ryan R. Burton and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions Between C1-Substituted 7-Oxanorbornadienes and Alkynes.”
Tetrahedron Lett. 2006, 47, 7185–7189.

63. Robert W. Jordan, Karine Villeneuve and William Tam*.
“Study on the Reactivity of the Alkyne Component in Ruthenium-Catalyzed [2+2]
Cycloadditions between an Alkene and an Alkyne.”
J. Org. Chem. 2006, 71, 5830–5833.

62. Alan J. Lough*, Karine Villeneuve and William Tam.
“Absolute configuration of the p-nitrobenzoate ester of the cycloadduct of ( S)-4-hydroxy-2-
pentynoate and acetic acid-8-acetoxy-1,4-dihydro-1,4-methanonapththalen-5-yl ester.”
Acta Cryst. 2006, E62, o2846–o2847.

61. Alan J. Lough*, Karine Villeneuve and William Tam.
“Ethyl 2-acetonyl-3-(1H-isochromen-1-yl)acrylate.”
Acta Cryst. 2006, E62, o2582–o2583.

60. Peng Liu, Robert W. Jordan, John D. Goddard* and William Tam*.
“Remote Substituent Effects in Ruthenium-Catalyzed [2+2] Cycloadditions: An Experimental
and Theoretical Study.”
J. Org. Chem. 2006, 71, 3793–3803.

59. Karine Villeneuve, Nicole Riddell and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions of Bicyclic Alkenes and Ynamides.”
Tetrahedron 2006, 62, 3823–3836.

58. Karine Villeneuve and William Tam*.
“Ruthenium-Catalyzed Isomerization of Oxa/azabicyclic Alkenes: an Expedient Route for the
Synthesis of 1,2-Naphthalene Oxides and Imines.”
J. Am. Chem. Soc. 2006, 128, 3514–3515.

57. Nicole Riddell and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions of Alkynyl Sulfides and Alkynyl Sulfones.”
J. Org. Chem. 2006, 71, 1934.

56. Karine Villeneuve and William Tam*.
“Ruthenium-Catalyzed Processes: Dual [2+2] Cycloaddition versus Cyclopropanation of
Bicyclic Alkenes with Propargylic alcohols.”
Organometallics 2006, 25, 843–848.

2005

55. William Tam*. (Invited Book Review)
“Ruthenium in Organic Synthesis.”
Angew. Chem. Int. Ed. 2005, 44, 6269–6270.

54. Woo-Jin Yoo, Anna Allen, Karine Villeneuve and William Tam*.
“Rhodium-Catalyzed Intramolecular [4+2] Cycloadditions of Alkynyl Halides.”
Org. Lett. 2005, 7, 5853–5856.

53. Nicole Riddell, Karine Villeneuve and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions of Ynamides.”
Org. Lett. 2005, 7, 3681–3684.

52. Woo-Jin Yoo, Gavin Tsui and William Tam*.
“Palladium-catalyzed Suzuki Coupling of 2,3-Dibromonorbornediene: Synthesis of 2,3-Diarylnorbornadienes.”
Eur. J. Org. Chem. 2005, 1044–1051.

2004

51. Karine Villeneuve, Nicole Riddell, Robert W. Jordan, Gavin Tsui and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions Between Bicyclic Alkenes and Alkynyl Halides.”
Org. Lett. 2004, 6, 4543–4546.

50. Robert W. Jordan, Peter R. Khoury, John D. Goddard* and William Tam*.
“Ruthenium-catalyzed [2+2] Cycloadditions Between 7-Substituted Norbornadienes and Alkynes: An Experimental and Theoretical Study.”
J. Org. Chem. 2004, 69, 8467–8474.

49. Alan J. Lough*, Karine Villeneuve and William Tam..
“5,6-[2α-Acetyl-1β-(ethoxycarbonyl)ethylidene]-1,3,3a,4,5,6,7,7a-octahydro-4,7-epoxy-isobenzofuran-1,3-dione.”
Acta Cryst. 2004, E60, o1659–o1660.

48. William Tam*. (Invited Mini Review)
“Recent Advances in Organometallic Chemistry Directed Towards Organic Synthesis.”
Chem. Int. 2004, 22–24.

47. Peter R. Khoury, John D. Goddard* and William. Tam.
“Ring Strain Energies: Substituted Rings, Norbornanes, Norbornenes and Norbornadienes.”
Tetrahedron 2004, 60, 8103–8112.

46. Alan J. Lough*, Karine Villeneuve and William Tam.
“(7S)-N-(4-Phenyltricyclo[4.2.1.02,5]non-3-ene-3-carbonyl)-2,10-camphorsultam.”
Acta Cryst. 2004, E60, o1566–o1567.

45. Karine Villeneuve and William Tam*.
“Asymmetric Induction in Ruthenium-Catalyzed [2+2] Cycloadditions Between Bicyclic Alkenes and Chiral Acetylenic Acylsultam.”
Angew. Chem. Int. Ed. 2004, 43, 610–613.

2003

44. Karine Villeneuve, Robert W. Jordan and William Tam*.
“Diastereoselective Ruthenium-Catalyzed [2+2] Cycloadditions between Bicyclic Alkenes and a Chiral Propargylic Alcohol and its Derivatives.”
Synlett 2003, 2123–2128.

43. Robert W. Jordan, William Tam and Alan J. Lough*.
“Ethyl 7-exo-acetoxy-4-phenyltricyclo[4.2.1.02,5]non-3-ene-3-carboxylate.”
Acta Cryst. 2003, E59, o1687–o1688.

42. William Tam, Alan J. Lough* and Robert W. Jordan.
“Ethyl 7-oxo-4-phenyltricyclo[4.2.1.02,5]non-3-ene-3-carboxylate.”
Acta Cryst. 2003, E59, o1685–o1686.

41. Alan J. Lough*, Robert W. Jordan and William Tam.
“Ethyl 4-Cyclohexyl-7-(dicyanomethylene)tricyclo[4.2.1.02,5]non-3-ene-3-carboxylate.”
Acta Cryst. 2003, E59, o1675–o1676.

40. Geoffrey K. Tranmer and William Tam*. (Invited Review)
“Bis(η2-ethene)(2,4-pentanedionato-O,O')rhodium.”
In "Encyclopedia of Reagents for Organic Synthesis [Online]", Editors: Paquette, L.; Rigby, J.; Wipf, P., John Wiley & Sons Ltd., article number RN00230, 2003, 6 pages.

39. Geoffrey K. Tranmer and William Tam*. (Invited Review)
“Bis(2-phenylindenyl)zirconium dichloride.”
In "Encyclopedia of Reagents for Organic Synthesis [Online]", Editors: Paquette, L.; Rigby, J.; Wipf, P., John Wiley & Sons Ltd., article number RN00229, 2003, 6 pages.

2002

38. Geoffrey K. Tranmer and William Tam*.
“Molybdenum-mediated Cleavage Reactions of Isoxazoline Rings Fused in Bicyclic Frameworks.”
Org. Lett. 2002, 4, 4101–4104.

37. William Tam*. (Invited Book Review)
“Topics in Current Chemistry 219. Cross-Coupling Reactions: A Practical Guide.”
J. Am. Chem. Soc. 2002, 124, 12630.

36. Peter D. Mayo and William Tam*.
“Ring-Opening Metathesis–Cross Metathesis Reactions (ROM–CM) of Substituted Norbornadienes and Norbornenes”
Tetrahedron 2002, 58, 9513–9525.

35. Peter D. Mayo and William Tam*.
“Palladium-Catalyzed Hydrophenylation of Bicyclic Alkenes.”
Tetrahedron 2002, 58, 9527–9540.

34. Peter D. Mayo and William Tam*. (Invited Review)
“Tris(acetoacetonyl)cobalt.”
In "Encyclopedia of Reagents for Organic Synthesis [Online]", Editors: Paquette, L.; Rigby, J.; Wipf, P., John Wiley & Sons Ltd., article number RN00084, 2002, 5 pages.

33. Geoffrey K. Tranmer and William Tam*.
“Palladium-Catalyzed Sonogashira Coupling of 2,3-Dibromonorbornadiene: Synthesis of Symmetrical and Unsymmetrical Norbornadiene-2,3-diynes.”
Synthesis 2002, 1675–1682.

32. Robert W. Jordan and William Tam*.
“Reactivity of the Alkene Component in the Ruthenium-Catalyzed [2+2] Cycloadditions between an Alkene and an Alkyne: Part 2.”
Tetrahedron Lett. 2002, 43, 6051–6054.

31. Marcel Schlaf*, Robert W. Jordan and William Tam.
“3-Ethoxy-7-methoxycarbonyl-4-phenyl-tricyclo[4.2.1.02,5]non-3-ene.”
Acta Cryst. 2002, E58, o629–o630.

2001

30. Robert W. Jordan and William Tam*.
“Study on the Reactivity of the Alkene Component in Ruthenium-Catalyzed [2+2] Cycloadditions between an Alkene and an Alkyne: Part 1.”
Org. Lett. 2001, 3, 2367–2370.

29. Peter Mayo, Galina Orlova, John D. Goddard* and William Tam*.
“Remote Substituent Effects on the Oxymercuration of 2-Substituted Norbornenes: An Experimental and Theoretical Study.”
J. Org. Chem. 2001, 66, 5182–5191.

28. Geoffrey K. Tranmer and William Tam*.
“Intramolecular 1,3-Dipolar Cycloadditions of Norbornadiene-Tethered Nitrones.”
J. Org. Chem. 2001, 66, 5113–5123.

27. Peter Mayo and William Tam*.
“Remote Substituted Effects on Regioselectivity in Pauson-Khand Reaction of 2-Substituted Norbornenes.”
Tetrahedron 2001, 57, 5943–5952.

26. Peter Mayo, Tiffany Hecnar and William Tam*.
“1,3-Dipolar Cycloaddition of Nitrile Oxides with Unsymmetrically Substituted Norborenenes.”
Tetrahedron 2001, 57, 5931–5941.

25. William Tam*, Geoffrey K. Tranmer and Alan J. Lough.
“6,9-Methano-4-methyl-3a,4,5a,6,9,10-hexahydro-5-oxa-1H,3H-furano[3,4-c]isoindol-3-one.”
Acta Cryst. 2001, E57, o269–o270.

24. Carol Yip, Sean Handerson, Geoffrey K. Tranmer, and William Tam*.
“Intramolecular 1,3-Dipolar Cycloadditions of Norbornadiene-Tethered Nitrile Oxides.”
J. Org. Chem. 2001, 66, 276–286.

2000

23. Robert W. Jordan and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions of 2-Substituted Norbornenes.”
Org. Lett. 2000, 2, 3031–3034.

22. Geoffrey K. Tranmer, Peter Keech, and William Tam*.
“Intramolecular 1,3-Dipolar Cycloadditions of 2-Substituted Norbornadiene-Tethered Nitrones.”
Chem. Commun. 2000, 863–864.

21. Geoffrey K. Tranmer, Carol Yip, Sean Handerson, Robert W. Jordan, and William Tam*.
“Synthesis of 2,3-disubstituted norbornadienes.”
Can. J. Chem. 2000, 78, 527–535.

20. William Tam*, Sean Handerson, and George Ferguson.
“2,3,3a,4,5a,6,7,8-Octahydro-5a-methyl-6,9-methano-1H,9H-5-oxa-4-azacyclopenta[c]indene.”
Acta Cryst. 2000, C56, e71.

1999

19. Peter Mayo, Marc Poirier, Jan Rainey, and William Tam*.
“Effect of a Remote Substituent on Regioselectivity in Oxymercuration of Unsymmetrical Substituted Norbornenes.”
Tetrahedron Lett. 1999, 40, 7727–7730.

18. Carol Yip, Sean Handerson, Robert Jordan, and William Tam*.
“Highly Regio- and Stereoselective Intramolecular 1,3-Dipolar Cycloadditions of Norbornadiene-Tethered Nitrile Oxides.”
Org. Lett. 1999, 1, 791–794.

1998

17. Mark Lautens* and William Tam. (Book Chapter)
“Transition Metal-Catalyzed Cycloadditions with Bicyclo[2.2.1]hepta-2,5-dienes.”
in "Advances in Metal-Organic Chemistry", Vol. 6, Chapter 2, pp. 49-101, Editor: Lanny S. Liebeskind, JAI Press, 1998.

16. Mark Lautens* and William Tam. (Book Chapter)
“Transition Metal-Catalyzed Enantioselective and Stereoselective Cycloaddition Reactions.”
in “Organometallic Reagents in Organic Synthesis”, Editor: Bateson, J.H. and Mitchell, M.B., Academic Press: London, 1998, p. 273.

1997

15. Anthony G.M. Barrett* and William Tam.
“Regioselective Ring Opening of Vinylcyclopropanes by Hydrogenation with Palladium on Activated Carbon.”
J. Org. Chem, 1997, 62, 7673–7678.

14. Anthony G.M. Barrett* and William Tam.
“Studies on Mercury(II)-Mediated Opening of Bi- and Tercyclo-propane Arrays.”
J. Org. Chem. 1997, 62, 4653–4664.

13. Mark Lautens*, William Tam, and James Blackwell.
“Synthesis of Highly functionalized Diquinanes by the Regio- and Stereoselective Cleavage of Homo-Diels-Alder Cycloadducts.”
J. Am. Chem. Soc. 1997, 119, 623–624.

1996

12. Mark Lautens*, Wolfgang Klute and William Tam.
“Transition Metal-Mediated Cycloaddition Reactions.”
Chem. Rev. 1996, 96, 49–92.

1995

11. Mark Lautens*, Alan J. Lough and William Tam.
“An Unusual trans-Fused Cyclopentane Ring System at 158 K.”
Acta Cryst. 1995, C51, 1944–1946.

10. Mark Lautens*, Alan J. Lough and William Tam.
“4-[(Trimethylsilyl)methyl]tetracyclo[5.4.0.06,10.09,11]undecan-3-yl-3,5-Dinitrobenzoate.”
Acta Cryst. 1995, C51, 471–473.

9. Mark Lautens*, Louise G. Edwards, William Tam, and Alan J. Lough.
“Nickel-Catalyzed [2+2+2] (Homo Diels-Alder) and [2+2] Cycloadditions of Bicyclo[2.2.1]hepta 2,5-dienes.”
J. Am. Chem. Soc. 1995, 117, 10276–10291.

8. Mark Lautens*, William Tam, Julia Craig Lautens, Louise G. Edwards, Cathleen M. Crudden and A. Catherine Smith.
“Cobalt-Catalyzed [2+2+2] (Homo Diels-Alder) and [2+2+4] Cycloadditions of Bicyclo[2.2.1]hepta-2,5-dienes.”
J. Am. Chem. Soc. 1995, 117, 6863–6879.

1994

7. Mark Lautens*, William Tam and Louise G. Edwards.
“Stereoselectivity in the Homo-Diels-Alder Reaction:  Effect of Remote 7-Substituent on Nickel Catalyzed Cycloadditions.”
J. Chem. Soc., Perkin Trans 1. 1994, 2143–2150.

1993

6. Mark Lautens*, William Tam and Christian Sood.
“Enantioselective Cobalt-Catalyzed [4+2+2] Cycloadditions.”
J. Org. Chem. 1993, 58, 4513–4515.

1992

5. Mark Lautens*, William Tam and Louise G. Edwards.
“Cobalt-Catalyzed Intramolecular Homo Diels-Alder Reactions.”
J. Org. Chem. 1992, 57, 8–9.

1990

4. William Tam. (Book)
“Worked Examples in Inorganic Chemistry: A study guide for the preparation of the Hong Kong Advanced Level and the GCE (London and Cambridge Board) A-Level Examinations.”
Lantco Publisher: Hong Kong, 1990, 153 pages. 

1989

3. William Tam. (Book)
“Worked Examples in Physical Chemistry: A study guide for the preparation of the Hong Kong Advanced Level and the GCE (London and Cambridge Board) A-Level Examinations.”
Lantco Publisher: Hong Kong, 1989, 311 pages. 

1988

2. William Tam. (Book)
“Suggested Solutions for the Hong Kong Advanced Level Examinations in Chemistry for the Past Ten Years: A study guide for the preparation of the Hong Kong Advanced Level and the GCE (London and Cambridge Board) A-Level Examinations.”
Lantco Publisher: Hong Kong, 1988, 588 pages. 

1. William Tam. (Book)
“Worked Examples in Organic Chemistry: A study guide for the preparation of the Hong Kong Advanced Level and the GCE (London and Cambridge Board) A-Level Examinations.”
Lantco Publisher: Hong Kong, 1988, 283 pages.

Publications

2021: CEPS Excellence in Undergraduate Teaching Award

2006 - 2008: University of Guelph Presidential Distinguished Professor Award (for Teaching and Research)

2007: University of Guelph Faculty Association Distinguished Professor Award (Teaching Award)

2007 - 2013: One of the Top 1% most cited chemists worldwide (Essential Science Indicators)

2000: Elected by the international journal SYNLETT as one of the 25 most outstanding starting Assistant Professors worldwide

2000: Boehringer Ingelheim Young Investigator Award for Organic Chemistry

1999: Ichikizaki Fund for Young Chemists

1996 - 1998: NSERC Postdoctoral Fellowship