New CLSI guidelines – enrofloxacin/ marbofloxcin
Durda Slavic
Animal Health Laboratory, University of Guelph, Guelph, ON.
AHL Newsletter 2024;26.
Susceptible-dose dependent (SDD) is a new interpretative category introduced by Clinical Laboratory Standard Institute (CLSI) guideline CLSI VET01S-ed7. SDD can be seen on AHL reports when minimal inhibitory concentration results are reported for antimicrobial susceptibilities. This category implies that susceptibility of an isolate depends on the dosage regimen. Currently, SDD category is only applicable in dogs when enrofloxacin or marbofloxacin is used in treatment of Enterobacterales (E. coli, Klebsiella, Enterobacter, etc.), Pseudomonas aeruginosa, and Staphylococcus spp. Based on MIC values, the following dosage regimes are recommended:
Reference
1. Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals, 7th ed. CLSI supplement VET01S. Clinical and Laboratory Standards Institute; 2024.